Colostrum products South Africa – Its effects on the whole body

Colostrum products South Africa – What are colostrum’s effects on the whole body?

Colostrum is the first food of life for newborn mammals. It provides antibodies, carbohydrates, and protein to help a baby grow and develop. Perhaps best of all, colostrum’s effects extend across the whole body.

Now, let’s take a look at 10 areas of the body where colostrum delivers immediate and long-lasting benefits.

  1. Colon: Friendly bacterial flora promotes a healthy acidity level in the colon, help treat constipation, diarrhea, and inflammatory bowel disease (IBD), and eliminate gastrointestinal (GI) infection and inflammation.
  2. Skin:The telomerase enzyme can replicate DNA by using RNA as a template. Colostrum also contains epithelial/epidermal growth factor for cell repair and regeneration, fibroblast growth factor that promotes wound healing, and insulin-like growth factor (IGF-1) that helps accelerate burn recovery.
  3. Joints: Growth factors help regenerate bone and cartilage tissue, transfer factors help reduce joint damage, pain, and stiffness, and the LMW peptide has been shown to reduce and prevent joint inflammation.
  4. Brain: Proline-rich polypeptides (PRPs) help improve the mental functioning of Alzheimer’s patients with mild to moderate dementia, and IGF-1 helps synthesize serotonin, inhibit age-related depression, and balance blood glucose in the brain.
  5. Adrenals: Lactoferrin helps regulate iron and reduce fatigue, and PRPs help modulate the body’s immune response. Plus, colostrum helps treat leaky gut syndrome (LGS), a leading cause of chronic disease.
  6. Sinus and Mouth: Lactoferrin plays a key role in the body’s ability to combat infection. Meanwhile, colostrum helps treat colds, food sensitivities, and influenza, and it has been shown to be more than three times as effective as vaccines against flu5.

 

7. Thyroid: Growth factors promote safe, effective management of immune disorders, and thyroid-stimulating hormone (TSH), thyroxine, and calcitonin support thyroid management.

8. Muscles: Growth hormone and IGF-1 help boost lean muscle mass. Additionally, colostrum helps prevent the digestion of muscle tissue.

 

 

9. Bones: Transforming growth factor (TGF) helps build bone, microcrystalline hydroxyapatite and DHEA help increase bone density, and growth factors help stimulate bone repair and regeneration.

10. Cells:IGF-1 is necessary to produce new cells, lactoferrin helps stimulate natural killer (NK) and immune cell activity, and immune and growth factors help prevent the spread of cancer cells.

 

11. The benefits of colostrum stretch beyond newborns too. In fact, there are many reasons why everyone should take colostrum, and these include:

  • Colostrum helps balance and maintain immune function. Immunoglobulins, lactoferrin, and PRPs help the immune system self-regulate and identify and mark pathogens for destruction.
  • Colostrum helps limit the risk of illness. Immunoglobulins, cytokines, interferon, lactoferrin, and PRPs help restore immunity, prevent infection, and speed up healing and recovery from illness.
  • Colostrum helps improve gut health. Growth factors and hormones help restore a leaky gut to normal permeability levels, and antibodies and immunoglobulins help control harmful bacteria and fungi.

Bovine colostrum products are available that have been shown to help people of all ages. By incorporating bovine colostrum into a regular diet, an individual can enjoy the benefits of colostrum every day.

Article- Douglas Wyatt – Sovereign Laboratories

Colostrum products South Africa – The Benefits of Colostrum

 

The Benefits of Colostrum

 

When mammals, including humans, are born the first food they receive is the mother’s colostrum. This pre-milk fluid is a wonder of nature, packed with nourishment – immune tonics, growth factors and a unique balance of vitamins and minerals.

Colostrum supports healthy growth and development and a naturally responsive immune system. It provides critical immune factors and complex lipids for overall health and wellbeing.

New Image is the market leader in products containing premium bovine colostrum. Because colostrum is non-species specific, bovine colostrum can be taken by humans. Colostrum is nature’s first food, of vital importance, and made available to you by New Image.

Colostrum benefits four aspects of the human body – it builds repairs, strengthens and restores:
  • The hormonal system back to levels associated with youth
  • The immune system to its top fighting form
  • The digestive system to its optimal function
  • And it even provides you with every basic essential nutrient

As cows produce far more colostrum than their calf requires, they can harvest the excess while maintaining strict animal welfare guidelines. Every batch of New Image colostrum is tested to ensure purity and compliance with industry and food safety guidelines.

Why you should take Colostrum everyday

Colostrum is a natural source of many bioactive compounds and valuable growth and immune factors that work synergistically to:

  • Improve your immune system and give greater health
  • Heal and protect the digestive tract
  • Enhance natural cellular repair, healing and tissue regeneration
  • Promote energy and vitality through healthy aging


 

Colostrum Products South Africa – Carb-Bal

Colostrum Products South Africa – Carb-Bal

 

Product Code: 61321

90 Capsules

Diabetics should have their blood sugar levels monitored by a health professional.

Not suitable during pregnancy and lactation. Always read the label and use as directed. This product is part of a weight management program. Your weight program should include professional healthcare advice on diet, exercise and lifestyle changes. This is not a meal replacement and appropriate advice on diet is important. Weight management programs take time and personal commitment to be effective. This product is intended for consumption only by persons 14 years and older.

Weight Management

Carb-Bal

Capsules

Enjoy a little more, absorb a lot less. Balances sugar cravings & keeps you on track.

  • Absorb fewer carbohydrates.
  • Supports your body in ketosis.
  • Safe & natural.
  • For best results, take with Alpha Lipid™ Ultra Diet™ 2.
  • Goal achieved? Maintain it with the help of Carb-Bal.

Balance: Regulates healthy blood sugar levels.

Armour: Helps balance carbohydrate intake.

Lightness: Lower carbohydrate intake means a lighter feeling you.

The natural ingredients in Carb-Bal capsules help balance the number of carbohydrates absorbed from your diet. They do this by inhibiting the activity of key enzymes (alpha-amylase) that break down starchy foods into easily absorbed sugars, this decreases the amount of carbohydrate and calories absorbed. Help curb sugar cravings naturally and feel healthy doing it!

Ingredients:

  • 210mg Gymnema (Gymnema Sylvestre) Dry Leaf – 21mg Concentrated Extract Equivalent
  • 2,500mg White Kidney Bean (Phaseolus Vulgaris) – 208mg Concentrated Extract Equivalent
  • 600mg Fenugreek (Trigonella Foenum-Graecum) Dry Seed – 150mg Concentrated Extract Equivalent
  • 5mg Chromium Yeast – 31ug Chromium Equivalent
  • Other Ingredients: Encapsulating Aids

Dosage:

For best results, take 1 capsule with water 30 minutes before meals, up to 3 times a day.

Source New Image


 

Colostrum products South Africa – What is Colostrum and what are its benefits?

Colostrum products South Africa – What is Colostrum and what are its benefits?

What is Colostrum and what are its benefits?

Colostrum and all it’s components such as lactoferrins, lactins, lactoperoxidase and approx. 50 other proteins are associated with the immuno-regulating process of the immune system. Colostrum is a potential growth supplement and immune modulator. Only colostral milk from the FIRST milking, following birth within the first 4 hours, is collected. Only cows that have calved two or more times are colostrum donors. Our Colostrum contains an immunoglobulin-concentration of min. 34% (typical 37%).

Important Components in Colostrum
Immunoglobulins (antibodies) are powerful specific and broad-spectrum antiviral and antibacterial defenders. Immunoglobulins are the most important and abundant immune factors found in Colostrum. There are five classes of immunoglobulins found in all mammals, including humans. (IgA, IgD, IgE, IgG, and IgM). Each has its own unique structure and job to do in the body. Colostrum contains all of the immunoglobulins. Lactoferrin is one of the most powerful antiviral, antibacterial substances, found naturally, only in bovine Colostrum (not species-specific). It has been shown to play a major role in our body’s defense against disease, infection, cancerous tumors and HIV.

 

Colostrum has everything… to give your body the very best of nature:

Immunoglobulins
IgG1
IgG2
IgM
IgAMinerals and Trace Elements
Calcium
Potassium
Phosphoric acid
Chloride
Sodium
Magnesium
Zinc
Iron
Manganese
Copper
Selenium
Chromium
MolybdenumAntimicrobic Substances
Lactoferrin
Lactoperoxidase
Lysozyme

Amino Acids
26 different essential Amino AcidsVitamin B
Thiamine
Riboflavin
Niacin
Folic Acid
Cobalamin
Pyridoxine
Pantothenic AcidGrowth factors
Insulin-like growth factor (IGF-1)
Colostral basic growth factor
(CBGF)Transforming growth factor
(TGF-B)Various
Creatine
Ascorbic Acid
L-Carnitine
Taurine
Choline
Biotine
Melatonine
Lactalbumin
FOR STRENGTH, VITALITY, AND ENDURANCE

Immune factors

Medical and clinical studies show immune factors in Colostrum neutralize:

  • Viruses,
  • Bacteria,
  • Yeast,
  • Fungus,
  • Allergens
  • Toxins.

Immunoglobulins

Have been shown to provide a superior defense both in treatment and prevention of viral infections, bacteria, and yeast. High-quality Colostrum must be certified to contain a minimum of 16% immunoglobulins.

Antibodies

Colostrum has been shown to contain specific antibodies that may help the body in its fight against specific diseases such as:

  • pneumonia,
  • RVS,
  • dysentery,
  • candida,
  • flu,
  • and numerous other illnesses.

 

PRP (Proline-rich Polypeptide)

Shown to possibly support and regulate the Thymus Gland (the body’s central command for the immune system), may help calm an overactive immune system and stimulate an underactive immune system.

 

Lactoferrin
A protein that has been shown to transport essential iron to our red blood cells and also keeps harmful bacteria and viruses from getting the iron they need to grow on.

 

Glycoproteins
(Protease inhibitors) A digestive factor that has been shown to help immune and growth factors survive the passage through the highly acidic digestive system.

Lactalbumins

Research indicates tremendous possibilities that Lactalbumins can be highly effective against numerous forms of cancer and viruses.

 

Cytokine’s: Interleukin 1 & 6, Interferon Y and Lymphokines
Shown to stimulate the lymph gland and are thought to be highly effective antiviral immune

 

Growth Factors: Anti-aging/Healing

  • Medical studies have shown the viral growth factors IgF-1 and TgF A & B and nucleotides from bovine Colostrum to be identical to human in composition.
  • Further, it has shown that they can help stimulate normal growth, regeneration and accelerated repair of aged or injured muscle, skin collagen, bone, cartilage and nerve tissues.
  • It helps stimulate the body to burn fat for fuel instead of the body’s own muscle tissue in times of fasting (diet). Helps BUILD LEAN MUSCLE.
  • It helps provide raw materials to repair vital DNA and RNA in the body’s cells.
  • It can help balance blood sugars (non-insulin diabetics and hypoglycemia).
  • It can be an effective topical application for burns, injuries and skin rejuvenation.

Vitamins & Minerals

Colostrum is not a supplement; it is the whole food for the newborn; it’s a combination of vitamins and minerals are naturally occurring and in perfect

Scientific and Medical Studies

Wilson, D.C, N.D, PH.D. James, 1998 Journal of Longevity, Vol.4, No 2; Immune System Breakthrough: Colostrum
“The most effective Colostrum is bovine. It’s much richer in immune factors than human Colostrum, particularly in the body’s most important immunoglobulin, IgG.” (Sandholm, 1997)
“Bovine Colostrum can supply an overtaxed body with more immunoglobulins than human Colostrum”
“IGF-1 has anabolic and tissue repair characteristics. IGF-1 is the only growth factor that can stimulate muscle growth and repair all by itself.” (Tollefsen, 1989)

Samson, R.R. et. Al., Immunology, 1975, Vol.38, No 2, 291-296
“Dr. Samson and associates found Colostrum was 21 times richer in Vitamin B-12 than milk. Research in 1975 confirmed that adequate Vitamin B-12 in the body doubles the body’s immune systems ability to fight disease.”

Sandholm et. Al., Acta Veterinaria Scandinavia, 1980, Vol.20 No 4 pp 469-476
“Bovine Colostrum was found to contain a powerful trypsin-inhibitor which protects Colostrum immunoglobulins from digestion. It was demonstrated that Colostrum from cows is richer in immune factors and inhibitors than Colostrum from humans.

 


 

Colostrum Products South Africa – Carb-Bal

Colostrum Products South Africa – Carb-Bal

 

Product Code: 61321

90 Capsules

Diabetics should have their blood sugar levels monitored by a health professional.

Not suitable during pregnancy and lactation. Always read the label and use as directed. This product is part of a weight management program. Your weight program should include professional healthcare advice on diet, exercise and lifestyle changes. This is not a meal replacement and appropriate advice on diet is important. Weight management programs take time and personal commitment to be effective. This product is intended for consumption only by persons 14 years and older.

Weight Management

Carb-Bal

Capsules

Enjoy a little more, absorb a lot less. Balances sugar cravings & keeps you on track.

  • Absorb fewer carbohydrates.
  • Supports your body in ketosis.
  • Safe & natural.
  • For best results, take with Alpha Lipid™ Ultra Diet™ 2.
  • Goal achieved? Maintain it with the help of Carb-Bal.

Balance: Regulates healthy blood sugar levels.

Armour: Helps balance carbohydrate intake.

Lightness: Lower carbohydrate intake means a lighter feeling you.

The natural ingredients in Carb-Bal capsules help balance the number of carbohydrates absorbed from your diet. They do this by inhibiting the activity of key enzymes (alpha-amylase) that break down starchy foods into easily absorbed sugars, this decreases the amount of carbohydrate and calories absorbed. Help curb sugar cravings naturally and feel healthy doing it!

Ingredients:

  • 210mg Gymnema (Gymnema Sylvestre) Dry Leaf – 21mg Concentrated Extract Equivalent
  • 2,500mg White Kidney Bean (Phaseolus Vulgaris) – 208mg Concentrated Extract Equivalent
  • 600mg Fenugreek (Trigonella Foenum-Graecum) Dry Seed – 150mg Concentrated Extract Equivalent
  • 5mg Chromium Yeast – 31ug Chromium Equivalent
  • Other Ingredients: Encapsulating Aids

Dosage:

For best results, take 1 capsule with water 30 minutes before meals, up to 3 times a day.


 

Colostrum Products South Africa – Alpha Lipid™ Lifeline™

 

Product Code: 7067

NAPPI CODE: 717899001

450g Can

Contains ingredients derived from dairy.

This product is not suitable for use by children under the age of 5 years old, except under advice from a medical practitioner.

Colostrum

Alpha Lipid™ Lifeline™

Supplemented Food Shake

Delicious Supplemented Food Shake

  • Support your immunity with 1600mg of Colostrum* containing 300mg of Immunoglobulins.
  • Improve your gut health & digestive comfort with 1 billion probiotics per dose.
  • Contains essential vitamins and minerals.
  • 1,000mg of calcium for healthy teeth and bones.
  • Assists the body’s natural repair process.
  • Best taken as a pre-breakfast cold drink or include it with your morning smoothie.

Defence:Colostrum’s natural antibodies build immunity through gut health.

Energy:Probiotics and proteins aid digestion, helping you feel more energised and balanced.

Focus:When you have the right balance of nutrients and a healthy digestive system to absorb them, your body and mind are naturally healthier and more focussed.

Alpha Lipid™ Lifeline™ breakfast drink combines colostrum and probiotics for powerful immune and digestive system support to help you feel balanced, healthy and strong.
*based on daily dose.

Ingredients:

  • 1680mg Bovine Colostrum
  • 300mg Immunoglobulins
  • 1,000mg Calcium
  • 1 Billion CFU Probiotics (Lactobacillus Acidophilus & Bifidobacterium)
  • Other Ingrediants: Dextrose, Skim Milk Powder, Minerals (Calcium, Phosphorous, Magnesium, Iron), Vegetable Gums (Guar Gum, Xanthan Gum), Complex Milk Lipid (Alpha Lipid™), Vitamins (C, E, B3, B5, A, D3, B6, B2, B12, B1, Folic, Biotin), Vanilla Flavour

Directions:

Take 30 minutes before eating.
1 ½ scoops (16g).
Mix with 150ml of either cold water or milk – shake well in a Turbo Shaker to combine.
This product is not recommended for use by children under the age of 5 years, except under advice from a medical practitioner.

 

 

Colostrum products South Africa – Colostrum improve the growth rate of many cell types

Colostrum improve the growth rate of many cell types

Colostrum
Colostrum is the initial milk or “first milk” that is produced by mammals (including humans) immediately following parturition. As expected, colostrum was more effective than milk with the total lipid, linoleic acid, linolenic acid, ganglioside, and glycolipid contents were higher in colostrum when compared to milk. In addition, with further analysis, the fat globule fraction provided the strongest stimulation for wound repair that contained Epidermal Growth Factors. The milk fluid produced by all female mammalian species after birth has the function to meet the complete nutritional requirements of the neonate and, at the same time, provide all of the biochemical needs and support the many biological functions of the immature newborn to help the newborn survive and develop. Starting in the 1980s and through the mid-1990s, supplemented cell culture medium with milk or colostrum was reported to improve the growth rate of many cell types including skin (fibroblasts). Peptides from milk protein hydrolysates improved the growth of human keratinocytes in culture. Medium supplemented with 300 μg/mL for 12 days where the average molecular weight of 800 Da containing a high concentration of amino acids promoted the growth of the keratinocytes by 108% (Vollmer et.al, 2018). Colostrum is the only known natural source of the enzyme, telomerase, which may help to slow down the aging of DNA. In fact, there is evidence that short telomeres and a lack of telomerase can exert a longevity-promoting effect via prevention of cancer (Hornsby et.al, 2007). Colostrum also includes EGF and IGF-1, which are known to assist in the repair and regeneration of cells. EGF and IGF-1 play essential roles in wound healing, which makes colostrum an important potential adjunct to the skin’s repair following a surgical cosmetic procedure. Let’s not forget about the lactoferrin in colostrum, either. Lactoferrin helps manage the immune response in the skin cells, which means supplementing with lactoferrin may potentially help a person increase his or her skin’s anti-inflammatory response (Blog sovereignlaboratories.com).

Selenium
Selenium (Se) is an essential trace element in the human body and plays an important role in the body via selenoprotein, which contains selenium. Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase-1 and endoplasmic reticulum-selenoproteins, etc.) have antioxidant effects and are involved in regulating antioxidant activities (Cai et.al, 2018). Se and the selenoproteins are essential for keratinocyte function and skin development. A lack of seleno-enzymes in the mouse epidermis leads to abnormalities in the skin and hair follicles, premature skin aging, and premature death. Additionally, several studies have shown that Se pretreatment can drastically protect keratinocytes, melanocytes, and fibroblasts from UV-induced cytotoxicity.  Low doses of Se were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the aged keratinocytes require four times more Se than the young keratinocytes to be protected from UVA-induced cytotoxicity (Favrot et.al, 2018; Jobeili et.al, 2013). Se protects keratinocyte stem cells (KSCs) against senescence via preservation of their stemness phenotype through adhesion to the basement membrane (Jobeili et.al, 2013). Wang et. al, 2017 showed that Vitamin C (250 mg/kg), vitamin E (250 mg/kg) and Se (0.2 mg/kg) exerted antioxidant effects and consequently may prevent skin damage caused by streptozotocin-induced diabetes (65 mg/kg) in Swiss albino rats.

Hyaluronic Acid
Hyaluronic acid (HA) is part of the body’s connective tissues and is known to cushion and lubricate. Aging destroys HA. Diet and smoking can also affect your body’s level of HA over time.  Skincare products with HA are most frequently used to treat wrinkled skin although they don’t replace anything the body has naturally lost. These are very effective moisturizers (WebMD. Understanding Skin Care Products). UV radiation damage causes initially a mild form of wound healing and is associated at first with an increase of dermal HA. As little as 5 min of UV exposure in nude mice caused enhanced deposition of HA, indicating that UV radiation-induced skin damage is an extremely rapid event. The initial redness of the skin following exposure to UV radiation may be due to a mild edematous reaction induced by the enhanced HA deposition and histamine release. Repeated and extensive exposures to UV ultimately simulate a typical wound healing response with deposition of scarlike type I collagen, rather than the usual types I and III collagen mixture that gives skin resilience and pliability (Papakonstantinou et.al, 2012). HA-based formulations (i.e., gels, creams, intra-dermal filler injections, dermal fillers, facial fillers, autologous fat gels, lotion, serum, and implants, etc.) exhibit remarkable anti-wrinkle, anti-nasolabial fold, anti-aging, space-filling, and face rejuvenating properties. This has been achieved via soft tissue augmentation, improved skin hydration, collagen and elastin stimulation, and face volume restoration. HA, alone or in combination with lidocaine and other co-agents, showed promising efficacy in skin tightness and elasticity, face rejuvenation, improving aesthetic scores, reducing the wrinkle scars, longevity, and tear trough rejuvenation (Bukhari et.al, 2018). Sparavigna et.al, 2019 reported significant improvement of wrinkles’ grade around the eyes, vertical lip lines and wrinkles’ severity of nasolabial folds after the first injection and the effect increased after the second injection. Aging/photoaging grade and surface microrelief improved 2 months after the first injection procedure. The treatments were very well tolerated by the volunteers as determined by the self-grading score. Lee et.al, 2019 reported that Cross-linked hyaluronic acid (CLHA) patches were not an irritant, whereas a clinical study showed that the application of single CLHA patches significantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days. Patch application also improved superficial wrinkles at the periorbital region for 3 days and at the nasolabial fold for 1 day. The absence of side effects indicated that the application of these CLHA microstructure patches is both safe and convenient for moisturization and anti-wrinkle effects. Jeon et.al, 2019 reported that CTP-EGF has superior ability, compared with natural EGF, to permeate the skin and induce HA synthesis and collagen formation. Thus, it has great potential to be used in cosmetics and therapeutic agents to improve wrinkles and the health of the skin. There exist many different types of HA gel fillers that differ in their HA concentration, particle size, cross-linking density, duration, and presence of lidocaine. High-density, large-particle fillers are recommended for deep dermal injections while low-density, small-particle filters are recommended for fine lines. HA gel is used by several healthcare professionals include the plastic surgeon, primary care provider, dermatologist, nurse practitioner and internist to enhance cosmesis. HA fillers are injected to restore volume lost due to age or disease, provide facial contour, and help maintain a youthful appearance. Filler injection has become one of the most commonly performed procedures in a dermatology cosmetic practice (Walker et.al, 2019).

Poly-L-lactic acid
Poly-L-lactic acid (PLLA) is an injectable filler used for restoring facial fat volume loss. Polydioxanone Cog thread and poly-L-lactic acid (PLLA) thread have been used clinically for lifting and antiaging purposes (Palm et.al, 2009). PLLA is an effective treatment for patients seeking to correct volume loss due to aging. Although the US FDA has approved PLLA for use in people with the HIV in 2004, it is well-suited for patients seeking cosmetic treatment. By 2009 PLLA was FDA-approved for the correction of nasolabial fold contour deficiencies and other lines and wrinkles. There have since been limited but promising results with off-label use of PLLA for non-facial volumization as well, including the hands, neck/décolleté, abdomen, and gluteal area (Jabbar et.al, 2017). PLLA is a safe, biodegradable volumizer used to reverse the signs of aging by gradually correcting volume loss. Patients should be aware of possible adverse reactions during the course of treatment (Palm et.al, 2009). Injection of PLLA in the deep dermis or subcutaneous tissue may cause an immediate augmentation of the treated tissue. This is a temporary but immediate response that is due to tissue edema and fluid from the reconstitution of the product. It will resolve within 2 to 3 days after injection. Once the carrier substance is absorbed, the poly-L-lactic acid particles induce an inflammatory response through phagocytosis by tissue macrophages. This is a similar process to suture reabsorption in the skin. The inflammatory response breaks down the poly-L-lactic acid into lactic acid monomers and is then metabolized to carbon dioxide and water while stimulating the production of new collagen type-I fibers in the skin. Approximately half of the product is digested within 6 months. The duration of action is 12 to 24 months (Sickles et.al, 2019). Kapicioğlu et.al, 2019 reported that PLLA and Cog sutures were effective in facial rejuvenation (studied in female rats); both increased dermis thickness and stimulated collagen production. Repeated PLLA treatments may improve skin quality in a time-dependent manner. Pigmentation, erythema, and pore size were significantly decreased, whereas radiance and smoothness were significantly increased at 12 months. No treatment-related adverse events occurred. Repeated PLLA treatments may improve skin quality in a time-dependent manner (Bohnert ET.AL, 2019). The process of hydration, loss of cohesion and molecular weight, and solubilization and phagocytosis of PLA by the host’s macrophages degrades PLA into lactic acid microspheres and eliminates CO2 by way of respiratory excretion. Crystals are left behind to stimulate collagen and a granulomatous reaction. This inflammatory reaction elicits resorption and the formation of fibrous connective tissue about the foreign body, causing dermal fibroplasia that leads to the desired cosmetic effect [2]. Kim et.al, 2019 reported that powdered polydioxanone injection induces collagen formation more effectively than PLLA injection (Ganceviciene et.al, 2012).

Hormone Replacement Therapy
In postmenopausal women, dermal collagen decreases, and skin becomes thinner (Warren et.al, 2015). Hormone replacement therapy (HRT) has been shown to be effective in alleviating menopausal symptoms. However, its use is controversial owing to potential health risks, such as thromboembolism and cancer. Bioidentical hormone therapy has also been used by dermatologists for its anti-aging effects on the skin, but little is known about the efficacy and side effects of bioidentical hormones in this field (Borda et.al, 2019). Women’s Health Initiative (WHI) study showed a higher risk for breast cancer, stroke, cardiovascular disease, and thromboembolic events with combined treatment of estrogens and progestin. Synthetic progestins mostly used worldwide include medroxyprogesterone acetate (most frequently used in the US), norethindrone acetate, cyproterone acetate, norgestimate, norgestrel, and dydrogesterone (Samaras et.al, 2014). The HRT impact on skin thickness and dermal density was demonstrated early when estrogens were initially administered to postmenopausal women. Such replenishment therapy was therefore considered as an attempt at alleviating in part skin atrophy and xerosis in postmenopausal women. Indeed, HRT controls in part the dermal thickness and laxity, and the collagen content and density, as well as the tissue mechanical reactivity, to stress (Piérard et.al, 2013). Physicians and patients have become extremely reluctant concerning HRT following the WHI study. Numbers of HRT prescriptions in the US rose from 58 million in 1995 to 90 million in 1999, corresponding to 15 million women per year. The numbers remained stable through to 2002. Within 3 months after publication of the results of the WHI study, prescriptions of various formulations of combined estrogens and progesterone dropped by 33% to 66% (Samaras et.al, 2014). Vinogradova et.al, 2019 reported an association between the risk of venous thromboembolism and different types of HRT. Transdermal treatment was the safest type of hormone replacement therapy when the risk of venous thromboembolism was assessed. Transdermal treatment appears to be underused, with the overwhelming preference still for oral preparations. Both oral and transdermal estradiol caused a significant decrease in FSH while only transdermal resulted in a significant decrease in LH. Oral estradiol, though not transdermal estradiol, increased serum high-density lipoprotein, thyroxine-binding protein, and growth hormone binding protein (Jospe et.al, 1995). Applying estrogen cream to the skin after menopause improves the external appearance of facial skin (Warren et.al, 2015). There is strong evidence that transdermal estradiol has a cardioprotective effect (Botelho et.al, 2014). Due to their lack of first-pass hepatic metabolism, transdermal products achieve clinical benefits while minimizing patient exposure to estrogens, which is consistent with the most recent clinical guidelines (Kopper et.al, 2009). Also, by increasing skin collagen content, and increasing acid mucopolysaccharides and HA, estrogen therapy encourages the growth and development of vaginal epithelial cells which make up the thick layers of the vaginal wall, and condone a moist, supple and elastic environment (Jenifer et.al, 2015). Botelho et.al, 2014 reported that nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. Abdi et.al, 2017 also concluded that the use of transdermal nano-formulations in hormone therapy can relieve climacteric symptoms and prevent other postmenopausal symptoms.

CONCLUSION
As more and more anti-aging and antioxidant skincare products flood the market, there is growing concern about definitions and experimental proof of   effectiveness. The physician has an important role in understanding which treatment options are appropriate for mild, moderate, and severe photoaging, and in educating patients on the risks and benefits of each. The choice of the right active compounds, the verification of their activity inside a cosmetic formulation, their   stability and synergistic effects should be the first step toward   the creation of modern and effective products.  To be active inside the skin, the antioxidants have to penetrate into the living layers of the skin, where free radicals are generated and should be effective against   ROS.  This is possible only if the topically applied formulation holds the potential to be effective. Moisturizing and emollient products are gaining increasing importance in dry skin treatment, maintenance of daily care of normal skin as well as ancillary therapy of many skin diseases. Consumers are nowadays more focused on their health and appearance. As a result, there has been an increasing demand in topical antiaging formulations with natural and nutraceutical ingredients. Novel and innovative delivery systems are transforming the new product development in the cosmetic field because of consumer perceivable benefits and optimized sensory attributes. The applications of novel drug delivery systems can be found in many cosmetic products. Nanomaterials are nowadays used in almost all major cosmetic industries. The truth is, there is no magic pill at present that will retard aging. But that is not to say there are not simple lifestyle and dietary adjustments that can make people live longer. A cosmetic product that produces clinically objective effects on the most-reported signs of aging is an attractive option for those unable to avoid extrinsic aging factors but wishing to improve their appearance without resorting to more invasive measures.

REFERENCES
1. Abdullah M, Attia FN. (2019); Vitamin C (Ascorbic Acid) In: StatPearls [Internet]
2. Abdi F, Darooneh T, Ghorbani M, Banihashemi F, Roozbeh N. (2017); Transdermal hormone replacement therapy with nanostructured medicines; Ginekol Pol; 88(2); 103-108
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Colostrum as an Anti-Aging Agent.

Bovine colostrum is one of nature’s greatest miracles. Its nutritional properties alone are of tremendous value to us. The highly beneficial immune and growth factors present in bovine colostrum offer considerable possibilities for the prevention and recovery of illnesses and disease. Colostrum also offers doctors, researchers, and the general population great hope in the quest for treatments that will help reverse the aging process.

Fountain of Youth Rediscovered?
Colostrum as an Anti-Aging Agent.   

By Donald R. Henderson, M.D., M.P.H. Assistant Clinical Professor of Medicine and Gastroenterology at UCLA School of Medicine

The search for youth started long before Spanish explorer Ponce de Leon roamed the New World seeking the fountain of youth. Much of that search, then and now, has focused on the superficial effects of aging – graying hair, wrinkles, and reduced endurance. However, aging is far more than the physical changes in our body’s appearance.

While “feeling old” may be a state of mind as well as a set of physical sensations, the aging process itself is a biological one. No matter how young we feel, our body goes through physiological changes as we get older. These changes bring about a decline in our ability to fight disease and infection. They also affect our central nervous system and alter our cellular structures, which, in turn, affect our muscles, skin, and skeletal form.

However, it is possible that the fountain of youth – or a part of it, anyway – has been found in colostrum. For the 63% of American adults who report they are concerned about the effects of aging*, and the 19 million people expected to be over age 85 by 2050 , this is great news.

But just how is colostrum able to do all this?

Colostrum: The Anti-Aging Connection

While changes due to aging in our cells, muscles and immune system sound like a series of irreversible processes, they can be slowed with colostrum because of the growth factors it contains. Among its myriad ingredients, colostrum contains:

Natural antibiotic factors:

  • immunoglobulins (IgG, IgA, IgD, IgE, and IgM) – substances that neutralize toxins, viruses, and bacteria, particularly in the digestive and respiratory systems
  • cytokines – small proteins that affect the behavior of other cells
  • lactoferrin – a substance that neutralizes bacteria and helps release cytokines
  • growth factors (IGF-I, IGF-II, EGF, TGF α & β) – substances that aid in cellular, muscular and skeletal growth

Immunoglobulins

Immunoglobulins, or antibodies, specifically recognize any foreign compound that enters the body. When one enters, various antibodies direct themselves to different areas of the invader and attack it, wherever it is in the body.

Over our lifetime, we are exposed to a variety of foreign substances and normally have built a vast array of antibody-producing lymphocytes (more than 100 million by some estimates) that persist at low levels for years. Their goal is to surface again if we are exposed to the same substance. The immune system is able to remember with what we have been infected, and often can prevent us from being infected again. This is the premise upon which vaccines work.

The most abundant antibodies in the bloodstream are of the immunoglobulin G class, IgG, but the IgA, IgD, IgE, and IgM classes are also important. These antibodies have similar structures but different functional properties. For example, Immunoglobulin A, or IgA, plays a key role in mucosal immunity, which is of particular importance in the maintenance of mucosal health and avoidance of infection, while IgG neutralizes toxins and microbes in the lymph and circulatory system.

Antibodies carry out two basic functions. First, they bind specifically to molecules from the foreign substance that caused the immune system to respond. Secondly, they recruit other cells and molecules to destroy the substance once the antibody is bound to it. Antibodies can also block receptors on cells and prevent viruses from entering cells.

When we think our antibodies are not responding well enough to something like an infection, we may take a series of antibiotics. But, by doing so, we reduce the body’s active immune response to that organism, whatever it may be. In essence, this means that the next time we face the same organism, our own immune response will likely be less effective than it otherwise would have been. Even when an antibiotic is properly prescribed and works as it should, it does not just kill the offending organism. It also kills others that perform important functions, such as the beneficial bacteria that aid in the breakdown and digestion of food, and help combat yeast overgrowth in the intestinal tract.

Any process that can replenish our natural antibodies and keep them strong has massive potential, and also has many implications. Imagine a natural food or supplement, such as colostrum, that provides a natural immunity against bacteria and viruses, allowing us to rely less on antibiotics. Using colostrum can assist our immune system.

Growth Factors

Although there are clearly many ingredients in colostrum that are of utmost importance, perhaps it is the growth factors that hold the most promise in slowing the aging process. Growth factors stimulate our skeletal and muscle growth on a cellular level while regulating our metabolism.

The growth factors contained in colostrum include:

  • epithelial growth factor (EGF)
  • insulin-like growth factor-I and II (IGF-I and IGF-II)
  • fibroblast growth factor (FGF)
  • platelet-derived growth factor (PDGF)
  • transforming growth factors alpha & beta (TG-α and TG-β)

Children need these growth factors to flourish. If they are absent, then growth-hormone therapy is prescribed. But such replacement therapy is not often done for adults, even though data indicates that adults who have abnormal body composition can benefit from growth-hormone replacement. Specifically, the researchers found that GH replacement in adults with growth-hormone deficiencies resulted in markedly beneficial alterations in body composition, fat distribution, and bone and mineral metabolism.

Growth hormone (GH) helps our long bones, joints and muscles grow. As we age, we create less GH, and we tend to experience osteoporosis and less lean muscle mass. Yet, several studies done in the 1990’s indicate that – at least in older men – the administration of GH can slow this aging process by lowering body fat content, increasing lean muscle mass, increasing bone-mineral density, and improving skin moisture and elasticity.

A study, found in the New England Journal of Medicine, concluded that GH treatment could prevent some signs of aging. Dr. Daniel Rudman treated 26 men between the ages of 61-80 with GH. He documented that his patients experienced a decrease in overall body fat, as well as an increase in bone density and lean muscle mass. He also reported an increase in the skin’s thickness and elasticity of these patients (Rudman 1990).

Another study found that long-term, low-dose growth-hormone treatment in mice significantly prolonged their life expectancy. Similar data even suggests that those without the needed levels of growth hormones have a much higher mortality rate (Khansari 1991)!

In my mind, this is certainly one of the top benefits of colostrum. Taking colostrum provides us with essential growth factors, immune factors, antibiotic factors, vitamins, minerals and antioxidants. It is a whole and complete food and/or supplement.

Each of the growth factors in colostrum helps stimulate cell and tissue growth by activating DNA formation. In fact, epithelial growth factor (EGF) is the growth factor that demonstrates the highest ability to stimulate epithelial (skin) regeneration on wounds (Bhora 1995).

EGF is a protein that helps protect and maintain the skin. When it is combined with insulin-like growth factors, it works even better – and this is what happens with colostrum. Unlike other supplements that provide only single growth factors, colostrum combines a complete package of growth factors that work together synergistically, as nature intended.

Most of the anti-aging effects of GH therapy are a result of increasing the body’s concentration of IGF-I and IGF-II. IGF-I and IGF-II are the most active ingredients found in bovine colostrum. They tell the body how to use the fat, sugar, and protein that it gets from food. They also control how cells grow and repair themselves. The fact that colostrum contains these growth factors, and that aging is a result of low levels of growth factors, suggests that colostrum could help counteract the biological aging process. Studies have shown that taking bovine colostrum by mouth can increase the body’s IGF-I levels (Antonio 1998).

IGF-I can also stimulate the growth and repair of DNA and RNA, the two most important ingredients in a cell (Francis 1988). DNA contains all our encoded genetic information, and RNA controls how we synthesize protein.

Bovine colostrum is the only natural source for IGF-I. IGF-I accelerates our healing process, balances our blood glucose and reduces the need for insulin, increases muscle mass and strength, and assists in bone growth and repair. In addition, IGF-I is capable of increasing T-cell production. And T-cells, the ones that help control our immune reactions, also release cytokines.

Cytokines

The benefits of using cytokines for the treatment of cancer were first made known by the book titled Quiet Strides in the War on Cancer, written by Steven Rosenberg in 1985. Since then, it has been popular that the cytokines found in colostrum have been one of the most researched protocols in the cure for cancer. Cytokines act as anti-inflammatories and help boost the production of other immunoglobulins(Goldman 1986;Hayashida 1994). As we grow older, however, our cytokine production is reduced by a significant extent. It also seems that cytokines might be responsible for regulating our immunological and metabolic responses (Playford 2005;Zimecki 2005).

Thus, as we age, we produce, and have access to, less of the essential substances that we need to maintain our health. It is estimated that colostrum triggers at least fifty processes in breast-fed infants. In adulthood, we should try to maintain that same level of nutrition through whole-food nutrition and dietary supplements. For this, colostrum is the natural choice. 

The Importance of a Healthy Digestive Environment

The digestive tract is the source of a vast majority of our body’s immunity. As infants take colostrum from the mothers’ breasts, the cells of the digestive organ begin to develop. Too often, we forget the relationship between what we eat and how the food is processed. If the cells and organs are not healthy, then even the best diet will be of no benefit. Simply stated, if our intestine is unusually permeable, then bacteria, viruses and other toxins may enter the bloodstream. This can lead to inflammation, food allergies, and a malabsorption of minerals. Some of the more common culprits causing a leaky gut include the use of non-steroidal anti-inflammatories (NSAIDs), antibiotics, birth control pills, caffeine, and alcohol. The result of a leaky gut is a compromised immune system (Deitch 1990).

Research has shown that colostrum can help maintain a healthy digestive environment and can prevent the development of a leaky gut. Moreover, the growth factors in colostrum play a key role by keeping the intestinal mucosa sealed and impermeable to toxins. Colostrum has been shown to prevent gastrointestinal tract injury caused by NSAIDs. It has been shown to provide the ingredients we need to help with nutrient absorption. In essence, colostrum’s anti-inflammatory factors help repair the damaged intestinal walls (Playford 1999).

Colostrum’s Future Impact

Research now underway is expected to yield even more concrete data about the impact colostrum has on our lives. Just a partial list of the ways bovine colostrum can potentially help us achieve and maintain optimum health and slow the aging process includes:

  • Rheumatoid Arthritis – because colostrum can reduce inflammation.
  • Osteoarthritis and Osteoporosis – because colostrum helps to build bone density.
  • Transplantation – immunoglobulins in colostrum could help reduce infection with fungus and bacteria.
  • Cancer Fighters – the cytokines in colostrum include the powerful interleukins.
  • Slowing of HIV – colostrum can reduce the infectious pathogens that cause related conditions.
  • Reduction in Obesity – colostrum can help the body better utilize the food it eats.
  • Effects of Aging – colostrum cream can moisturize and even repair skin (via epithelial growth factor) to help reduce the effects and appearance of aging.

Conclusion

Bovine colostrum is one of nature’s greatest miracles. Its nutritional properties alone are of tremendous value to us. The highly beneficial immune and growth factors present in bovine colostrum offer considerable possibilities for the prevention and recovery of illnesses and disease. Colostrum also offers doctors, researchers, and the general population great hope in the quest for treatments that will help reverse the aging process.on